CELL PHONES AND CHILDREN: Review of Israeli bill/warnings and Weizman ERK study

SUBJECT:    CELL PHONES AND CHILDREN  -   Review of Israeli bill/warnings and Weizman ERK study (2008); also study re electric field effects on receptors and signaling….(UK) 2002….

Dear Iris:   Thank you very much for the information re Israeli bill (warnings) and ERK study re children and cell phone usage!

The following is an important study that may provide additional insight and explanations regarding cell receptors and cell signaling re cell phone usage.   The study also provides important clues that may explain why my guinea pig (Z-1, Kelley) so quickly developed osteomyelitis after exposure to our electric meter and also why her wound healed so quickly once she was removed from the electric meter’s electric field.

It is encouraging that facts re cell phone use are correlating with studies re other close electric field exposures.   “Encouraging,” but “frightening and scandalous” that parents are not being warned about the vital need to provide distance between appliances and telephone equipment in bedrooms.    Even the American Cancer Society provided warnings re electric clocks, electric blankets and more as far back as 1993 (File 2 RAD IRIS 2 –  “USA Today” article warning re bedroom electric field exposures).

Parents and grandparents need to know they also should not be sleeping close to cell phones, electric meters, appliances and other telephone equipment    Note the connection between ERK and tau protein and neurofibrillary tangles in Alzheimers’ in definition following the study copied below.     As we know, Alzheimers and autism-spectrum disorders are “exploding!”     Since autism is typically diagnosed around the age of two years, concerns re close exposures to cell phones, in general and, in particular, close to an expectant mother’s body or a cell phone on nightstand or under pillow (or other electric or telephone equipment) where a new mom might place an infant, are highly significant!

It would be an important step to include evaluation of such ”nightly exposures” in studies re cell phone usage.   In the meantime, I am grateful for this extremely important action and information out of Israel!   The story is unfolding …….     Take care  -  Joanne

Joanne C. Mueller
Guinea Pigs “R” Us
731 – 123rd Avenue N.W.
Minneapolis, Minnesota  55448-2127 USA
Phone:   763-755-6114
Email:    jcmpelican@aol.com (6-17-08)

WEBSITE:  http://guineapigsrus.org

ARE YOU AND YOUR CHILDREN GUINEA PIGS?    Letter 7-22-04 by Joanne Mueller
http://omega.twoday.net/stories/282050/

All truth goes through three stages: first it is ridiculed:  then it is violently opposed: finally it is accepted as self evident.    – Schopenhauer

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http://www.fasebj.org/cgi/content/full/16/8/857

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FJ EXPRESS SUMMARY ARTICLE The Full-length version of this article is also available, published online April 10, 2002 as doi:10.1096/fj.01-0811fje.

Published as doi: 10.1096/fj.01-0811fje.

This Article Full Text (PDF) All Versions of this Article: 16/8/857 01-0811fjev1 most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by ZHAO, M. Articles by MCCAIG, C. D. Search for Related Content PubMed PubMed Citation Articles by ZHAO, M. Articles by MCCAIG, C. D.

(The FASEB Journal. 2002;16:857-859.)
© 2002 FASEB

Membrane lipids, EGF receptors, and intracellular signals colocalize and are polarized in epithelial cells moving directionally in a physiological electric field¹

MIN ZHAO², JIN PU, JOHN V. FORRESTER^* and COLIN D. MCCAIG² Departments of Biomedical Sciences and
^* Ophthalmology, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK

²Correspondence: Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK. E-mail: m.zhao@abdn.ac.uk or c.mccaig@abdn.ac.uk

SPECIFIC AIMS

Endogenous electric fields (EFs) are common where cell movement occurs, and cells respond to EFs by migrating directionally. We set out to determine whether a physiological EF induces spatially regulated formation, migration, and activation of membrane lipid domains, associated receptors, second messenger signaling molecules, and the actin cytoskeleton in epithelial cells, which could underpin directional cell migration.

PRINICIPAL FINDINGS

1. Asymmetric distribution of membrane lipid, EGF receptors, and signaling molecules in a physiological electric field
Corneal epithelial cells (CECs) from fresh bovine eyes cultured in medium with 10% fetal calf serum (FCS) migrated toward the cathode. In serum-free medium, directional migration was lost. Addition of transforming growth factor (TGF), which activates EGF receptors (EGFRs), causing downstream activation of MAP kinase, restored and significantly enhanced migration directedness and migration rate in a dose-dependent manner. Asymmetric distribution of EGF receptors in live and fixed epithelial cells labeled with specific antibodies was evident (Fig. 1 A–C), and this occurred as early as 10 min after the onset of EF application (Fig. 1B ). Further quantification of the asymmetry showed membrane and juxtamembrane asymmetry of EGFRs in cells cultured in EFs. In most polarized cells, asymmetry of intracellular EGFR staining was also evident………..snip

[ File note:  This study is very long but VIP and includes charts......search result re "ERK" (externally regulated kinases  ---  extracellular signal-regulated kinase)... review re Israeli bill(2008)/ Weizman Institute study cellphones and children re ERK ......and also Uckun re BTK (Bruton's Tyrosine Kinase)  --   esp osteomyelitis/guinea pig Z-1 and low IgG subclasses 1 and 3 -- Boy A and Boy B........jcm....6-17-08 ..]

^{PK40(erk) protein kinase}

^{<enzyme> A member of the erk family of serine/threonine-proline kinases; hyperphosphorylates tau protein in neurofibrillary tangles of alzheimer’s disease subsequent to phosphorylation by camp-dependent protein kinase a; has been sequenced}

^{Registry number: EC 2.7.1.-}

^{Synonym: pk40(erk2), erk2 brain kinase pk40}

^{(26 Jun 1999)}

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In a message dated 6/17/2008 7:00:39 A.M. Central Daylight Time, atzmonh writes:

A new bill is presented in Israel to limit the sell and use of cell phones by kids.

The bill was filed by MPs Dov Hanin Michael Malchior with nine more MPs. According to the new bill, any advertising of mobile phone will include a warning, that will catch 5% of the advertisement page. Children will not be shown in the advertisement and it will not be directed to children.  Chidren will not be able legally to buy themselves a cell phone (only with an adult).  It will not be legal to sell phones without a warning. The warning will say, on a patch of at least the size of 5 cm, “Warning: the health ministry warns that a lot of usage and  carrying the device close to the body can increase the risk of cancer, especially among children.”   Warnings on the damage will be at the sale centers of cell phones, services centers and on the companies’ websites.  Backgroud: the Knesset (parliament) meeting on the 8 October 2007,  in which prof Roni Seger presented Weizmann institute study results, about the reaction of protein  ERK to the mobile radiation.  While it is not clear whether there is a clear link to cancer, the results do raise concern especially in view of the  use of  children. So it is suggested to increase public awareness to the health damage. The basis of the bill is to limit advertising and sale of cell phones, especially the sale to children who are especially volnurable to the devestating effects of the mobile radiation. The health minister will determine the damage  and it will be criminal not to fill the directions of the bill,  similar to the directions in the law of tobacco advertisement.

(all the above is translated and summerized from the bill itself).

In other countries:

http://sify.com/news/fullstory.php?id=14695318

http://news.yahoo.com/s/ap/20080527/ap_on_bi_ge/japan_no_cell_phones

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Mechanism of a short-term ERK activation by electromagnetic fields at mobile phone frequency

http://omega.twoday.net/stories/3662948/